Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O | the enzyme shows 6fold faster adenine removal compared to DNA containing a guanine:adenine mismatch. However, under conditions where the concentration of the enzyme is much lower than the concentration of DNA, 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine substrates are not quantitatively converted to product due to the inefficient turnover resulting from slow product release | Escherichia coli | ? | - |
? | |
DNA containing a guanine:adenine mismatch + H2O | - |
Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
adenine glycosylase | - |
Escherichia coli |
mutY | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays an important role in the prevention of DNA mutations resulting from the presence of the oxidatively damaged lesion 7,8-dihydro-8-oxo-2'-deoxyguanosine in DNA by the removal of misincorporated adenine residues in 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mispairs and also exhibits adenine glycosylase activity toward adenine in guanine:adenine and cytosine:adenine mismatches | Escherichia coli |